Transformative Science and Technology Solutions

---

Novel reformulation of genome assembly and related tasks as graph-traversal optimisation (QUBO/HUBO), solved with Iterative-QAOA. Developed methodology to reintegrate computational solutions back into biology. 

https://academic.oup.com/bib/article/27/1/bbag084/8499369 

https://arxiv.org/abs/2604.06106 

Developed hybrid quantum-classical pre-processing algorithms that losslessly shrink the input graph, paired with a tailored QAOA solver for the Maximum Weighted Clique problem. Demonstrated on IBM Heron r3 recovering more maximum-weight cliques than classical solvers.

Exact, information-conserving encoding of whole genomes as quantum states, using matrix product state depth–width trade-offs and index-reported verification. 

World-first: the complete Hepatitis-Delta virus genome successfully loaded onto NISQ hardware.

https://arxiv.org/abs/2508.06184 

A novel correlation-preserving encoding with no known classical or quantum analogue. Developed RotorMap which delivers a dramatic speedup over Minimap2 for long, noisy-read mapping. Developed a quantum DNA authentication protocol with evidence of quantum advantage in communication complexity.

https://arxiv.org/abs/2603.22245